zhijie wei , Xin Chen

The School of Life Sciences and Technology, Tongji University, Shanghai, 20082
Author    Correspondence author
International Journal of Molecular Medical Science, 2020, Vol. 10, No. 6   
Received: 27 Apr., 2020    Accepted: 09 May, 2020    Published: 10 May, 2020

This article was first published in Genomics and Applied Biology in Chinese, and here was authorized to translate and publish the paper in English under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In order to learn more about the pathogenesis and the gene expression feature of the colorectal cancer (CRC), we used the RNA-seq data from GEO database, to find out the biological implications of the CRC relative mRNA and lncRNA. In the meantime, we used the known annotation information and bioinformatics software to predict the potential lncRNA. According to the comparison of healthy and tumor samples, we did the differentially expressed analysis to mRNA and lncRNA, and inferred their function and the relationship with the CRC. We found out 1 032 differentially expressed genes in total, 164 of them were lncRNA. In GO and KEGG enrichment analysis, they were enriched the CRC relative pathways. There were 219 new lncRNA we found with confidence, which have connection with CRC. All the above results explored the lncRNA activities in CRC, and they may offer reference to the disease diagnosis.

Colorectal cancer; Different expression analysis; Predict new lncRNA